West Asia conflict escalates sharply as Iran launches missiles at Israel on sixth day of warfare. US submarine sank Iranian warship, prompting Iranian retaliation and threats to regional military and economic infrastructure. Fighting intensified across multiple fronts including Lebanon where Israeli strikes target Hezbollah positions. Supreme Leader Ayatollah Ali Khamenei killed in initial strikes. Death toll exceeds 1,000 in Iran, 70 in Lebanon, dozen in Israel. Global oil and gas supplies disrupted significantly. International shipping routes snarled. Hundreds of thousands of travelers stranded across West Asia. US Senate Republicans rejected resolution to halt military campaign. President Trump praised military operations. Conflict aims and timelines remain unclear, suggesting prolonged engagement ahead.